ETHNIC BELONGING OF THE UZBEK POPULATION
Аннотация
Clinically important genes СYP1А1, СYP2С9, СYP3А4 were studied for the first time in 217 healthy volunteers in Uzbek population. The frequencies of minor alleles СYP1А1*2С, СYP2С9*2, СYP3А4*1В were 6.7, 9.4, and 3.2%, respectively and corresponded to those in the Caucasians. For 3 alleles the genotype frequencies were in accordance with Hardy–Weinberg equilibrium. The absence of homozygous СYP1А1*2С, СYP2С9*2, СYP3А4*1В was revealed. Of 217 persons 86.6, 81.1, and 93.5% were homozygous for wild alleles, 13.4, 18.9 и 6.5% were heterozygotes for СYP1А1*2С, СYP2С9*2, СYP3А4*1В, respectively. The observed heterozygotes were shown to prevail over the expected ones for СYP1А1*2С, СYP2С9*2.
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